Lack of diversity in genomic research hinders precision medicine for nonwhite Americans

June 19, 2019

The vast majority of genomic data scientists have collected focuses on people of European descent, overlooking minority populations. As genetic-based precision medicine grows, this data gap means minorities may lack access to medical care that could reduce growing chronic disease disparities among racial and ethnic groups.

Precision medicine is an approach that allows doctors to select treatments that are most likely to be effective in protecting a patient’s health or treating their disease, based on an understanding of the patient’s individual genes, environment and lifestyle. This approach allows doctors and researchers to better predict which treatments and prevention strategies will work for which people, but it can’t be used effectively without access to accurate information for that particular individual or group.

A team of researchers from institutions across the country, including the University of North Carolina at Chapel Hill, analyzed phenotypes of nearly 50,000 non-European individuals, identifying 65 new associations and replicating 1,400 associations between genes and diseases, highlighting the need for equitable inclusion of diverse populations in genetic research.

Dr. Misa Graff

Dr. Misa Graff

Dr. Kari North

Dr. Kari North

Kari North, PhD, a professor in the Department of Epidemiology at the UNC Gillings School for Global Public Health, and Misa Graff, PhD, assistant professor in same department, are co-authors on the paper “Genetic Diversity Improves Our Understanding of Complex Trait Architecture,” which was published June 19 in Nature. North was the senior co-leader and oversaw the research and Graff was a co-junior lead.

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Gillings School team receives $6.2 million to study metabolic underpinnings of obesity-associated cardiovascular disease

May 15, 2019

Penny Gordon-Larsen, PhD — a professor in the Department of Nutrition and associate dean for research at the UNC Gillings School of Global Public Health — and a multidisciplinary team of researchers have been awarded a $6.2 million grant from the National Institutes of Health’s National Heart, Lung and Blood Institute to study how the body’s metabolic processes influence obesity-related cardiovascular disease (CVD).

The team also is led by Christy Avery, PhD, associate professor in the Department of Epidemiology, Kari North, PhD, professor in the Department of Epidemiology, and Susan Sumner, PhD, professor in the Department of Nutrition, who will work with Gordon-Larsen on the study “Leveraging multi-omics approaches to examine metabolic challenges of obesity in relation to CVD” to better understand the biologic mechanisms behind obesity’s impact on metabolic pathways and how they relate to CVD.

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North honored with Diversity and Disparities Leadership Award

November 13, 2018

Dr. Kari NorthDr. Kari North of the Gillings School’s Department of Epidemiology will be awarded the 2018 Shiriki Kumanyika Diversity and Disparities Leadership Award at the international ObesityWeek conference in Nashville. This award recognizes an investigator whose research has made a significant difference in the area of obesity-related disparities and who has exhibited leadership in mentoring new investigators. Congratulations, Dr. North!

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UNC Researchers Conduct Most Diverse Genetic Study of Female Reproductive Milestones to Date

August 2, 2018

A new study is the first to examine multiple genes that influence the age at which a woman starts her period (menarche) and experiences menopause among a large sample of United States women of diverse ancestries. Several minority groups of women in the U.S., particularly African-American and Hispanic/Latina women, experience these milestones on average earlier than white women do – a fact that places female members of these racial and ethnic groups at greater risk for certain cardiovascular diseases and cancers.

“Although these population-level differences are likely due in large part to greater exposure to non-genetic risk factors like obesity or smoking, we know very little to date about the underlying genes involved in early menarche and menopause among U.S. minority women,” said Dr. Lindsay Fernández-Rhodes, the corresponding author of the study. “Therefore, we have to do a better job of identifying which genes are involved in order to understand how they interact with obesity, smoking and other public health priorities.”

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Postdoc Heather Highland Discusses Diversity with ASHG TV

October 20, 2017

At the 2017, American Society for Human Genetics Annual Meeting in Orlando, Florida, ASHG TV is joined by Heather Highland, a Post-Doctoral Fellow at the University of North Carolina Chapel Hill, to talk about why diversity in science matters, and what are some strategic and effective strategies for achieving representation in Genomics.

Study identifies novel gene loci for traits related to obesity

May 3, 2017

Scientists from the University of North Carolina at Chapel Hill’s Gillings School of Global Public Health have joined with a collaborative of international researchers to explore whether and how smoking tobacco may alter one’s genetic susceptibility to obesity and distribution of body fat.

Their findings, published April 26 in Nature Communications, suggest that smoking can and does produce such genetic changes – and that more research should be focused upon discovering specific interactions among genes, obesity and environmental exposures.

Dr. Anne Justice

Dr. Anne Justice

Dr. Kari North

Dr. Kari North

Anne E. Justice, PhD, postdoctoral fellow in epidemiology, and Kari North, PhD, epidemiology professor, are key authors of the study.

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